Will the Latics feel the Ferguson backlash?
Nemanja Vidic looks set for his first Manchester United appearance of the season after overcoming a calf injury.
Antonio Valencia is expected to start against his former club after coming on as a second-half substitute against Burnley on Wednesday.
Wigan could name an unchanged line-up for the third game running.
Charles N’Zogbia’s fitness is rated at 50/50 but other than long-term absentee Olivier Kapo, Wigan have a clean bill of health.
Doubtful: N’Zogbia (unspecified)Injured: Kapo (knee)
Injured: Ferdinand (thigh), Hargreaves (knee), Obertan (unspecified), Rafael (shoulder), Van der Sar (hand) (BBC Sport)
Sir Alex Ferguson is the kind of manager who can make the most of an unexpected defeat and lead his side to an immediate turn of fortune so Roberto Martinez may well be worried his side may bear the brunt of Man United’s defeat at Turf Moor.
Vidic will hope to be back from injury and Luis Antonio Valencia is sure to get a good reception on his return to the side he represented with such great effect for three seasons.
My Prediction: 2-0 to United.