Manchester United reported no new injuries following their midweek Champions League trip to Besiktas.
Rio Ferdinand remains doubtful with a groin problem, while Paul Scholes is suspended.
City defender Micah Richards has recovered from a bout of tonsillitis and Stephen Ireland is optimistic about overcoming an ankle injury.
Carlos Tevez and Roque Santa Cruz are extremely doubtful and Emmanuel Adebayor begins his three-match ban.
Suspended: Scholes (1 match)
Doubtful: Ferdinand (groin), Rafael (shoulder)
Injured: Hargreaves (knee), Obertan (back), Van der Sar (thumb)
Suspended: Adebayor (3 matches)
Doubtful: Ireland (ankle), Kompany (ankle), Santa Cruz & Tevez (knee)
Injured: Benjani (hip), Johnson (groin), Robinho (ankle) (BBC Sport)
Four straight wins since the Burnley debacle should stand us in good stead for this huge derby today, but we must of course take into account the incredible start to the season Man City have had and this should be one hell of a match-up at Old Trafford.
Mark Hughes is obviously going to miss the fire power of strikers Adebayor, Santa Cruz, Tevez and Robinho so that should help us no end but if the intelligent Ireland is fit for the game then he is someone we are going to have pay extra attention to.
I will be hoping for Anderson to again be firing on all cylinders as he has been the past two games and that could give our midfield that extra edge and help our attacking impetus.
My Prediction: 1-0 to United