Old Trafford plays host to a Tottenham side ready to cement first ever Champions League spot.
Tottenham midfielder Wilson Palacios is available after suspension.
Jermaine Jenas played 45 minutes of friendly against West Ham on Tuesday as he continues his comeback from a groin injury.
Manchester United defenders Rio Ferdinand and Wes Brown both return to the squad.
Ferdinand has overcome a groin problem and Brown has recovered from a broken toe, but Owen Hargreaves is sidelined with a calf strain.
Injured: Anderson (knee), Hargreaves (calf), Owen (hamstring)
Doubtful: Jenas (groin)
Injured: Cudicini (broken wrists), Lennon & Woodgate (both groin), Kranjcar (ankle) (BBC Sport)
This fixture always brings its fair share of goals and a great deal of excitement but with both sides having so much to play for we could be in for an even more of a spectacle than usual.
Tottenham will be buzzing after successive wins over Arsenal and Chelsea and can probably leave Old Trafford with a point and feel they are still favourites for fourth spot but the fact that they have failed to beat Man United in any of their previous 21 encounters will surely have an affect on the club’s players.
The north London side will also be mindful of the manner in which they blew a two goal lead in this fixture a year ago when strikes by Darren Bent and Luka Modric were cancelled out by a second half onslaught.
Sir Alex Ferguson will need his side to be firing on all cylinders and need all three points to keep the pressure on Premier League leaders Chelsea.
Here are some highlights of previous fixtures between the two sides to whet the appetite.
Man United 5-2 Tottenham April 2009
Tottenham 5-1 Man United October 1965
Tottenham 3-5 Man United September 2001