Sir Alex takes his Old Trafford side to the Stadium of Light for a crucial Premier League encounter.
Manchester United welcomed back forward Wayne Rooney and defender Rio Ferdinand to training on Friday with both hopeful of returning to the starting XI.
Gary Neville, who has signed a new one-year contract at Old Trafford, is touch and go with a calf problem.
Sunderland are without the suspended Alan Hutton, meaning Phil Bardsley could start against his old club.
Lee Cattermole and John Mensah are hoping to return from injury, but George McCartney and Andy Reid are out.
Suspended: Hutton (one match)
Doubtful: Cattermole (calf), Mensah (knee)
Injured: McCartney & Reid (both hamstring)
Doubtful: Ferdinand & Rooney (both groin), Neville (calf)
Injured: Anderson (knee), Owen (hamstring) (BBC Sport)
Sir Alex takes his Man United side to Sunderland knowing nothing less than a win will do. Once again Ferguson will hope he can call upon Wayne Rooney as he has seen his side struggle without the England man. Steve Bruce’s side do not have a great deal to play for but they did manage to come away from their earlier meeting this season with a point.
Here are some highlights from when these two teams went head to head earlier in the season.
Manchester United 2-2 Sunderland October 2009