Favourites begin their campain in Durban.
Spain striker Fernando Torres is likely to play a part off the bench as he is eased back after a knee injury, so Vicente del Bosque could opt for a five-man midfield with David Villa playing as a lone striker.
Andres Iniesta is winning his fitness battle and may start, so Cesc Fabregas is likely be on the bench.
Switzerland are missing captain Alex Frei, who has an ankle injury, so Eren Derdiyok will take his place in attack.
West Ham midfielder Valon Behrami has also been ruled out by coach Ottmar Hitzfeld. (BBC Sport)
To view highlights of the Spain-Switzerland game CLICK HERE
Spain are everyone’s favourites for this summers World Cup but Vicente del Bosque will have been making sure his players have their heads in the right place and that complacency hasn’t set in. They find themselves in a very easy looking group but having seen many teams struggle against supposedly inferior opposition will have hopefully made the European Championship holders well aware of the task ahead of them, not least given Spain have of course never won the World Cup.
There is no arguing though the talent on offer to the Spanish coach. Its a squad chock full of Champions League winners and title holders from various leagues and perhaps most importantly its a side who is bang in form. Switzerland will be their usual resilient selves under Ottmar Hitzfeld who is as experienced a coach as there is at this World Cup. Expect a cagey defensive display from Senderos and co but if David Villa gets going or Fernando Torres is raring to go then it could be a very long afternoon for the Swiss.
Highlights of warm up games the two teams have recently played in.
Spain 6-0 Poland
Switzerland’s Road to South Africa 2010