Ghana hope to make it two from two in Rustenburg.
Australia could make wholesale changes to their side following their 4-0 thrashing by Germany. Tim Cahill is suspended so Harry Kewell is likely to start up front and he may be partnered by Josh Kennedy.
Defensive midfielder Vince Grella has been ruled out with a knee injury.
Ghana have no injury worries and could pick the same XI that impressed in beating Serbia 1-0, which means Kevin-Prince Boateng is set to keep his place and win only his third cap for Ghana.
One booking from suspension: Vorsah, Tagoe (Ghana); Moore, Neill, Valeri (Australia). (BBC Sport)
Australia are rightfully considering a raft of alterations to the side humbled by Germany. They go into the game without Tim Cahill who was harshly sent off in that encounter and know that they need something from this encounter to stand any chance of progressing.
Ghana on the other hand doggedly won past Serbia in their first game and will go into this Rustenburg encounter with renewed confidence.
Highlights of preview World Cup group games these two sides have taken part in.
Germany 4-0 Australia
Serbia 0-1 Ghana