Its all to play for in this Group D Johannesburg battle.
Germany coach Joachim Loew has said that it is possible he may make one or two changes to his team and will decide with his coaching staff at a meeting on Tuesday night.
Miroslav Klose is banned so Cacau, who scored against Australia, is likely to play up front
Ghana’s John Mensah and Issac Vorsah have returned to training after missing the match with Australia due to calf and knee problems respectively.
Sulley Muntari has been disciplined for his actions at the end of the draw with Australia, but has apologised and remains in the squad.
Suspended: Klose (Germany) One game from suspension: Vorsah, Tagoe, Jonathan Mensah, Addy, Annan (Ghana); Cacau, Khedira, Lahm, Oezil, Schweinsteiger (Germany) (BBC Sport)
Group D is very finely balanced and all four sides can still theoretically progress but Ghana will be kicking themselves for not overcoming ten men Australia in their last clash and must now hope to avoid defeat against Germany in Johannesburg.
Joachim Low’s side thrashed Australia in their opener but were strangely subdued against Serbia but did have to play for most of that match with ten men after having Miroslav Klose unfairly sent off.
Highlights of previous World Cup group games these two have taken part in.
Ghana 1-1 Australia
Germany 0-1 Serbia