Johannesburg is the setting for this must win Group F encounter.
Slovakia could recall fit-again winger Miroslav Stoch after creating few chances in the defeat to Paraguay. Marek Cech could also return in place of defender Kornel Salata, who admitted to feeling nervous against the Paraguayans.
Italy are also expected to make changes after two disappointing performances, with forwards Antonio Di Natale and Giampaolo Pazzini pressing for a start.
Playmaker Andrea Pirlo is available after returning from a calf injury but is likely to start on the bench.
One booking from suspension: Strba, Durica, Sestak, Weiss (Slovakia); Camoranesi (Italy) (BBC Sport)
Its win or bust for Marcello Lippi and he will be hoping his Italian side finally clicks into gear after two very average performances in a group that the reigning World Cup holders should really have walked through. There appear to be very real problems in attack as the likes of Alberto Gilardino and Vincenzo Iaquinta fail to get going leaving the door open to the likes of Di Natale and Pazzini, two players who had a terrific Serie A season last term.
Slovakia still have a chance of making it into the knock out stages but need to win in order to do so, making this a game that is likely to be very open and attacking.
Highlights of previous World Cup group games these two have taken part in
Italy 1-1 New Zealand
Slovakia 0-2 Paraguay