Winner takes all.
Chile have two key players suspended – playmaker Matias Fernandez and combative midfielder Carlos Carmona. Jorge Valdivia is an obvious replacement for Fernandez, while Rodrigo Millar may come in for Carmona after recovering from a calf strain.
Spain forward David Villa has avoided a retrospective ban for slapping Honduran Emilio Izaguirre. He will again be partnered by Fernando Torres, while midfielder Andres Iniesta has recovered from the minor leg injury that prompted him to sit out the win over Honduras. (BBC Sport)
Its winner takes all in Pretoria as Chile and Spain go head to head knowing nothing less than a win will guarantee progress to the last 16.
Highlights of previous World Cup group games these two sides have taken part in.
Chile 1-0 Switzerland
Spain 2-0 Honduras