The Gunners travel to Anfield for what many hope will be an early season classic.
Liverpool’s new signing Christian Poulsen, who arrived from Juventus on Thursday, could go straight into the Reds’ midfield.
Fernando Torres has recovered from the groin injury he picked up at the World Cup but may start on the bench.
Arsenal will leave it late to decide whether Cesc Fabregas and Robin van Persie are fit enough to feature.
Summer signings Marouane Chamakh and Laurent Koscielny are in the squad, and Jack Wilshere is pushing for a start.
Doubtful: Torres (groin) Injured: Skrtel (ankle)
Doubtful: Denilson (abdominal), Diaby & Song (both calf), Fabregas & van Persie (both fitness)
Injured: Bendtner (groin), Djourou (hamstring), Ramsey (broken leg) (BBC Sport)
This promises to be a fascinating fixture as two top four chasing sides go head to head at Anfield in a fixture that always tends to excite. Roy Hodgson takes charge of his first Premier League match as Liverpool boss and a number of players will get their league debuts for the club as will those who Arsene Wenger brought in over the summer.
Both sets of fans have high expectations after pretty average seasons last term and this game will go some way to showing if either could be genuine title challengers and whether dreams of at least a Champions League spot can be achieved.
There are big question marks over whether Fernando Torres will be fit for action but it seems he may miss out and Arsenal have a number of players out and the likes of Cesc Fabregas and Robin Van Persie face late fitness tests to decide if they will take part.
Obviously one player the Liverpool side should take extra care marking would be Russian Andrei Arshavin who has managed five goals on his two previous trips to Anfield.
Pre-match press conference with Arsene Wenger
Highlights of the classic match from April 2009
Liverpool 4-4 ArsenalArsenal 1-0 Liverpool February 2010Join the Best Football Manager game now, Its Free!