Old Trafford outfit travel to Goodison Park for early kick off.
Everton midfielder Jack Rodwell has been ruled out for up to three months with damaged ankle ligaments.
Louis Saha will be missing after he lasted only 10 minutes of his international return for France, but captain Phil Neville is fit.
Manchester United’s Rio Ferdinand could make a comeback, but Anderson is doubtful and Michael Carrick is out.
Wayne Rooney is likely to play against his former club despite the furore surrounding his private life.
Doubtful: Neville (foot)
Injured: Anichebe & Saha (both knee), Rodwell (ankle), Yakubu (calf/shin)
Doubtful: Anderson & Ferdinand (both knee)
Injured: Carrick (Achilles), Hargreaves (knee) (BBC Sport)
Wayne Rooney will be talk of the town as he returns to his old stamping ground and does so with a furore over his private life to boot. David Moyes will hope that he can pick up Everton’s first win of the season after a poor start to the season.
Sir Alex Ferguson is hopeful that Rio Ferdinand will play some part in a match for the first time this term but the Toffees arguably have bigger selection headaches having lost crucial pair Louis Saha and Jack Rodwell and will hope that Phil Neville will be fit to face his former club.
David Moyes pre-match press conference
Sir Alex Ferguson pre-match press conference
Highlights of previous Premier League matches these two have taken part in this season.
Aston Villa 1-0 Everton
Manchester United 3-0 West Ham