Under fire Upton Park boss Avram Grant will hope he can prevent an onslaught from their Stamford Bridge opponents.
West Ham’s new signings Victor Obinna and Lars Jacobsen could make their debuts on Saturday.
Robert Green and Valon Behrami are fit again, but Thomas Hitzlsperger and Danny Gabbidon are injury doubts.
Chelsea captain John Terry is fit after a hamstring strain, but Frank Lampard has not recovered in time from hernia surgery.
Gael Kakuta has overcome a back problem to be included in the squad, while Ramires is hoping for his first start.
Doubtful: Gabbidon (hamstring), Hitzlsperger (thigh)
Injured: Collison, Hines & Kurucz (all knee)
Injured: Bosingwa (knee), Ivanovic (back), Lampard (groin) (BBC Sport)
This London derby is always an explosive encounter and with Avram Grant hoping to end a 100% losing start to the season the Hammers will be hoping more than ever to slow the Premier League champions after their impressive start to the campaign.
Frank Lampard is set to miss out a visit to his former club but John Terry is fit for the trip to Upton Park. After scoring 14 goals in their first three games the Blues will hope to maintain their stranglehold on top spot whilst West Ham will hope that new signings Victor Obinna and Lars Jacobsen could spark their east London side into life.
Carlo Ancelotti pre-match press conference
Highlights of previous Premier League matches these two sides have taken part in this season.
Man United 3-0 West HamChelsea 2-0 Stoke CityJoin the Best Football Manager game now, Its Free!