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Manchester United will be without defenders Chris Smalling (tonsillitis) and Jonny Evans (calf strain).
Rio Ferdinand could be named among the substitutes following a recent back problem but Phil Jones is likely to start after overcoming illness.
Blackburn manager Steve Kean has 10 senior players either ruled out or doubtful for the trip to Old Trafford.
Rovers will monitor David Dunn, Junior Hoilett and Martin Olsson, all of whom are nursing hamstring problems.(BBC Sport)