The Latics take on Man United at Old Trafford.
Manchester United midfielder Darren Fletcher returns to the squad for the visit of Wigan after 10 months out with a serious bowel problem.
Robin van Persie and Shinji Kagawa were injured on international duty but are expected to be available, while Wayne Rooney (gashed leg) is still out and Ashley Young (knee) is doubtful.
Wigan may be without Jean Beausejour (hamstring) and Antolin Alcaraz.
Midfielder James McArthur should be fit despite nursing a back injury.
Fletcher, 28, has not played for United since November last year when he decided to take an extended break from football.
“Darren Fletcher is in the squad,” said manager Sir Alex Ferguson. “At this moment in time everything looks fine.” (BBC Sport)
Man United: Lindegaard, Rafael, Ferdinand, Vidic, Buttner, Nani, Carrick, Scholes, Giggs, Hernandez, Welbeck. SUBS: De Gea, Evans, Valencia, van Persie, Cleverley, Powell, Kagawa
Wigan Athletic: Al Habsi, Boyce, Caldwell, Figueroa, Ramis, Beausejour, McArthur, McCarthy, Maloney, Di Santo, Kone. SUBS: Pollitt, Watson, Crusat, Jones, Gomez, Boselli, Miyaichi
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