Spurs boss Andre Villas-Boas plays a strong side in Greece, with French ‘keeper Hugo Lloris making his second Europa League start in goal and Michael Dawson are returning at centre-back to captain to side.
There is also a place for Tom Huddletsone, while the front three of Aaron Lennon, Jermain Defoe and Gareth Bale keep their places.
PANATHINAIKOS XI: Karnezis; Seitaridis, Triantafyllopoulos, Pinto, Vyntra; Vitolo; Zeca, Marinos; Christodoulopoulos, Owusu-Abeyie; Toche
Subs: Kotsolis, Sissoko, Mavrias, Fornaroli, Barbarouses, Chouchoumis.
SPURS XI: Lloris, Walker, Dawson, Caulker, Vertonghen, Huddlestone, Dembele, Dempsey, Lennon, Bale, Defoe.
Subs: Cudicini, Gallas, Sandro, Townsend, Falque, Mason, Sigurdsson