The Blues travel to Romania to take on Steaua Bucharest.
Chelsea’s comes just days prior to an FA Cup quarter-final against Manchester United at Old Trafford, meaning Rafa Benitez may be inclined to rest key players.
Only Yossi Benayoun (ankle) and Oriol Romeu (knee) are expected to miss out through injury, but John Terry (knee) may not be risked following a fairly stuttering return from a spell on the sidelines.
Fernando Torres is expected to start with Demba Ba being rested ahead of the weekend’s FA Cup clash.
Romanian champions Steaua come into the tie with almost a full squad to choose from as Laurentiu Reghecampf looks to continue his side’s impressive run in the competition.
Daniel Georgievski (fibula) remains out for the hosts but, aside from the Georgian defender, Steaua can call upon a full-strength side.
Brazilian forward Adi Rocha could come back into the side in place of Stefan Nikolic, while Cristian Tanase should retain his role in the starting line-up despite receiving a red card during the win over Gaz Metan at the weekend.
Gardos • Chiriche? • Râpa • Latovlevici
Prepelita • Chipciu • Tanase • Adrian Popa
Adi • Rusescu
Azpilicueta • Ivanovic • Luiz • Bertrand
Lampard • Ramires
Moses • Oscar • Mata
Chelsea and Steaua have never met in a competitive match.
From their last 12 away matches in the Europa and Champions League, The Blues have three wins.
Chelsea’s two Europa League goals so far this season have been scored in the final 15 minutes of ties.
Steaua have scored eight times in the last 15 minutes of European matches this season, 42 per cent of their overall output.