Having suffered a shock defeat to the Danes last week, this game will represent a prime opportunity for Louis van Gaal to regain some credibility in on the European stage.
However, the game, like most Europa League encounters, has come at a difficult time as injuries and future fixtures will have to be taken into account.
With that in mind, we’re picking the predicted starting XI they’ll field in what could be a tense night at Old Trafford.
Ex-Arsenal, Liverpool, Chelsea star wants controversial sex-tape striker at Euro 2016
Barcelona star reveals the key behind Arsenal triumph
£200k-per-week Manchester United transfer target reveals he wants to play for Real Madrid
GK: Sergio Romero
Despite having a run out on Monday, he’ll likely keep his spot in goal with David de Gea saved for this weekend’s meeting with Arsenal.
RB: Donald Love
The young Scot has impressed with his forays into the first team so far and will likely be given another chance to shine.
CB: Chris Smalling
United’s shortage at the back means Smalling may be seeing more game time than is ideal this week.
CB: Daley Blind
The Dutchman has been filling in the heart of the defence more and more this season and is expected to do so again on Thursday.
LB: Cameron Borthwick-Jackson
Another youngster that has been thrown in at the deep end this term and another youngster that has impressed despite the stifling responsibility.
CM: Morgan Schneiderlin
The Frenchman will be expected to keep things ticking over through the middle.
CM: Ander Herrara
The creative foil to Schneiderlin. The Spaniard will look to drive the team forward and get involved with the forwards.
RM: Jesse Lingard
Lingard has stepped his game up immeasurably this season and is quickly proving himself as a key component to their midfield.
CAM: Juan Mata
Mata has been blowing hot and cold this season, but one moment of magic could make all the difference.
LM: Memphis Depay
Memphis has already admitted that he has not been good enough this term, and this fixture could turn out to be the catalyst for better things.
ST: Anthony Martial
With Rooney out, it’s all down to the teenager to lead the line and produce the goods.