Manchester United take on Southampton for the 119th time in all competitions today at Old Trafford.
Record signing Paul Pogba has been included in the squad and is expected to make his official debut for the Red Devils.
Zlatan Ibrahimovic is also in the provisional squad while Chris Smalling returns from suspension and Jesse Lingard returns after missing the opening day through injury.
United target Jose Fonte could return to the Saints team after missing the 1-1 draw against Watford but Ryan Bertrand is still out.
United have won 61 of the previous 118 encounters with the Saints recording 28 victories since records began.
Southampton do however, have a pretty good record at Old Trafford and are unbeaten in their last three visits to the stadium. United have not actually beat the Saints at Old Trafford since 2013.
Manchester United v Southampton
Stadium: Old Trafford
Kick-Off: 20:00 GMT
Man United possible starting lineup:
De Gea; Valencia, Blind, Bailly, Shaw; Fellaini, Pogba; Martial, Rooney, Mkhitaryan; Ibrahimovic
Manager: Jose Mourinho
Southampton possible starting lineup:
Forster; Cedric, Fonte, Van Dijk, Targett; Hojbjerg, Ward-Prowse, Davis; Tadic, Redmond, Long
Manager: Claude Puel
Follow Emre Sarigul @Turkish_Futbol