Tottenham take on Stoke City at the Bet365 stadium hoping to close the gap with third placed Manchester United to just one point.
Transfer deadline signing Moussa Sissoko has been included on the bench and could make his debut if he is brought on at some stage over the 90 minutes.
Star striker Harry Kane starts up front for the North London based outfit despite failing to score this season.
Stoke have included Egyptian summer signing Ramadan on the bench and fellow transfer window arrival Wilfried Bony will start upfront alongside Arnautovic.
Bony joined the Potters on a one-year loan from City over the summer to provide additional firepower.
The Ivory Coast international struggled at City last season but had an impressive record during his time at Swansea City prior to joining the Citizens.
Stoke go into the game in last place having picked up just one point in their first three games – losing the other two matches.
Stoke City v Tottenham
Tottenham starting line-ups: Lloris (C); Walker, Alderweireld, Vertonghen, Davies; Dier, Wanyama; Eriksen, Alli, Son; Kane
Subs: Vorm, Trippier, Carter-Vickers, Winks, Lamela, Sissoko, Janssen
Stoke starting line-ups: Given; Cameron, Shawcross, M. Indi, Pieters; Whelan, Allen, Imbula; Walters, Bony, Arnautovic
Subs: Grant, Bardsley, Muniesa, Adam, Crouch, Bojan, Ramadan
Follow Emre Sarigul @Turkish_Futbol