Wenger takes his men on a short journey to east London.
Scott Parker returns from a one-match ban for struggling West Ham, while Kieron Dyer (hamstring) could feature.
Mexico international forward Guillermo Franco is hoping for his debut after building his fitness in the reserves.
Arsenal goalkeeper Manuel Almunia is fit again after six weeks out with a virus and is pushing for a recall.
Striker Eduardo is expected to return from injury, but Niklas Bendtner (groin) and Tomas Rosicky (knee) are doubtful.
Suspended: None Doubtful: Dyer (hamstring)
Injured/unavailable: Ashton (ankle), Boa Morte (knee), Davenport (leg)
Doubtful: Bendtner (groin), Nasri (fitness), Rosicky (knee)
Injured: Denilson (back), Djourou & Walcott (knee) (BBC Sport)
West Ham have not had the season many had predicted this term and find themselves second from bottom and showing little of the promise Gianfranco Zola had instilled in them last term but that being said they have been most unfortunate with long term injuries and have not had the luck they needed on the field of play losing some games they didn’t deserve to.
We have been on a fine run of form ourselves and are unbeaten in eight but we were not all that convincing against AZ but hopefully we should have too much for the Hammers on Sunday.
My Prediction: 2-0 to Arsenal.