The favourites get an immediate chance of salvation against Group H whipping boys.
Spain coach Vicente Del Bosque is considering a recall for striker Fernando Torres alongside David Villa, with defensive midfielder Sergio Busquets set to make way.
Defender Sergio Ramos should overcome a rib injury, while Andres Iniesta is doubtful following a heavy challenge that forced his substitution against Switzerland.
Honduras could again be without Inter Milan forward David Suazo, who missed their opening game with a thigh muscle injury.
One booking from suspension: Wilson Palacios (Honduras) (BBC Sport)
Highlights of this match will be posted on this site as soon as the final whistle is blown. You can also see every World Cup goal that is scored the moment its up online and you can do that by CLICKING HERE.
Switzerland’s win over favourites Spain was perhaps the shock of the World Cup thus far but luckily for Vicente del Bosque he gets the chance to bounce back immediately against minnows Honduras. With all due respect to their Central American opposition, David Villa, Fernando Torres and co should be able to pick up their first three points of the campaign in Johannesburg.
Highlights of World Cup group games that these two have taken part in.
Spain 0-1 Switzerland
Honduras 0-1 Chile