Diego Forlan will be hoping to add to his World Cup tally in Port Elizabeth.
Uruguay are expected to stick with the same line-up that beat Mexico 1-0 in their final group game. Coach Oscar Tabarez may be tempted to bring in defender Diego Godin in place of Mauricio Victorino, who is one booking away from suspension.
South Korea coach Huh Jung-moo could drop fullback Cha Du-ri, who was at fault for Nigeria’s opening goal in their 2-2 draw, with Kim Dong-jin favourite to replace him.
One booking from suspension: Yeom Ki-hun, Lee Chung-yong, Kim Nam-il (South Korea); Victorino, Lugano, Fucile (Uruguay). (BBC Sport)
Port Elizabeth is the setting for the first match of the last 16 and the South Americans must feel that they have a good shot of making it to the Quarter Finals after an impressive group stage and will be banking on strike pairing Luis Suarez and Diego Forlan being too much to handle for a Korean back four who conceded six goals in their opening three matches.
Highlights of previous World Cup matches these two have taken part in.
Mexico 0-1 Uruguay
Nigeria 2-2 South Korea