National rivals go head to head in Cape Town.
Spain midfielder Xabi Alonso is a major doubt with a sprained ankle, so Javier Martinez is on standby to replace him. Reserve defender Raul Albiol is definitely out of this match after damaging ankle ligaments during training.
Deco is available again for Portugal after a hip injury, so coach Carlos Queiroz must decide whether to restore him to the starting line-up. Hugo Almeida or Liedson will come back into the team as Danny is expected to miss the game with a badly bruised leg.
One booking from suspension: Almeida, Coentrao, Duda, Mendes, Pepe, Ronaldo, Tiago (Portugal) (BBC Sport)
Spain have not looked entirely convincing thus far in South Africa and have not exactly set the tournament alight as many had expected them to. Portugal have also only been operating on half power and their North Korean thrashing aside Carlos Queiroz will not have been too impressed with the way his side have performed.
Both sides have the chance to really get going as they go head to head in this mouthwatering encounter in Cape Town as local rivals battle for a Quarter Final spot where they will feel they face a relatively easy encounter against either Paraguay or Japan.
Highlights of previous World Cup 2010 group games these two have taken part in.
Chile 1-2 Spain
Portugal 0-0 Brazil