Blues only need a point from Stamford Bridge tie to qualify as Group F winners.
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Chelsea will rest a number of their first-team regulars against MSK Zilina in the Champions League on Tuesday night.
Goalkeeper Petr Cech and striker Nicolas Anelka will be missing, while coach Carlo Ancelotti gives a first-ever start to teenage midfielder Josh McEachran.
The Blues are without injured John Terry (thigh); Frank Lampard (tendon), Yuri Zhirkov (calf), John Mikel Obi (knee), Alex (knee) and Yossi Benayoun (Achilles).
Jeffrey Bruma will play alongside Branislav Ivanovic at the heart of the defence.
Team (from): Turnbull, Hilario, Cech, Ferreira, Bosingwa, Bruma, Ivanovic, Cole, Van Aanholt, Ramires, McEachran, Malouda, Drogba, Kalou, Kakuta, Sturridge, Borini, Sala. (Daily Mail)
Even with an understrength team, Chelsea will expect to secure the point needed to top Group F at home tomorrow night.
In Slovakia, Chelsea triumphed 1-4 thanks to goals from Michael Essien, Daniel Sturridge and a brace from Nicolas Anelka, and in London they will hope to keep up their 100% record in the competition.
Josh McEachran looks a fine talent in midfield, and once he has bulked up with some gym work could be Chelsea’s first youth product for some time to make it through the ranks at Stamford Bridge.
He has already seen himself called into the England U21 squad at the age of just 17, and the slower pace of the UEFA Champions League would seem to suit his game more in the immediate future than the hustle and bustle of the Premier League.
In addition, Jeffrey Bruma will hope to prove to Carlo Ancelotti that he is the man to solve Chelsea’s defensive crisis, with Blues centre halves Alex and John Terry both struggling with injuries.
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