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Arsenal manager Arsene Wenger has hinted he will rest players suffering from fatigue or minor injuries, such as Robin van Persie, Theo Walcott, Aaron Ramsey and Abou Diaby.
There could be rare starts for forward Park Ju-young and Alex Oxlade-Chamberlain.
Manchester City pair Mario Balotelli and Gareth Barry are both suspended.
Owen Hargreaves, who is fit after a recent calf injury, Kolo Toure and Stefan Savic could all feature. (BBC Sport)