Saints play host to Aston Villa.
Southampton newcomers Gaston Ramirez and Maya Yoshida could make their full debuts, having featured as substitutes in the 6-1 defeat by Arsenal.
Jos Hooiveld hopes to overcome a calf problem, while fit-again midfielder Jack Cork is in contention to make his first appearance of the season.
Villa summer signing Christian Benteke could make his first start after his goalscoring cameo against Swansea.
Midfielders Chris Herd and Fabian Delph are available after injuries. (BBC Sport)
Southampton: Gazzaniga, Clyne, Yoshida, Schneiderlin, Fonte, Lambert, Davis, Ramirez, Fox, Lallana, Puncheon: SUBS: Davis, Rodriguez, Ward-Prowse, Do Prado, Richardson, Mayuka, Seaborne
Aston Villa: Guzan, Lowton, Vlaar, Clark, Lichaj, Holman, El Ahmadi, Ireland, Bannan, Benteke. Bent: SUBS: Given, Bowery, Agbonlahor, N’Zogbia, Weimann, Westwood, Bennett
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