The Magpies travel to Old Trafford.
Manchester United are expected to hand fit-again midfielder Darren Fletcher his first start for 10 months.
The Red Devils will rotate their squad, so Angelo Henrique could make his debut, while Nick Powell, Alex Buttner and David de Gea may also play.
Newcastle duo Fabricio Coloccini and Cheick Tiote could make their comebacks from injury at Old Trafford.
The game will come too soon for Tim Krul and Danny Simpson, but they are expected back in training this week. (BBC Sport)
Manchester United: De Gea, Vermijl, M Keane, Wootton, Buttner, Fletcher, Cleverley, Anderson, Rooney, Welbeck, Chicharito
Newcastle United: Elliot; Perch, Williamson, Coloccini (c), Tavernier; Obertan, Tiote, Gosling, Marveaux; Vuckic; Shola Ameobi
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