White Hart Lane plays host to visitors from Switzerland.
Spurs host Swiss pacesetters Basel in the first leg, a pairing that ostensibly favours Andre Villas-Boas’ men.
“I think hopefully going past Basel would mean a lot to the club — being present in a European semi-final.
“We dream of winning trophies so our focus on the Europa League won’t shift,” said Villas-Boas.
Tottenham will welcome back Gareth Bale from suspension after the Welsh star missed Spurs’ 4-1 defeat at Inter Milan that saw the north Londoners limp through on away goals.
Basel have never defeated an English side on their travels, but Manchester United’s untimely Champions League exit at the hands of the Swiss outfit last season should serve as a warning not to underestimate them.
Tottenham striker Jermain Defoe is out of the Europa League quarter-final first leg tie against Basel with a groin injury.
Defoe could be sidelined for up to 10 days and is also likely to miss Sunday’s league game against Everton.
Goalkeeper Hugo Lloris has recovered from a knee injury suffered in France’s World Cup qualifier against Spain.
Sandro and Younes Kaboul are still out, but Clint Dempsey is back in the squad after playing for the United States.