RW: Luis Nani
With club-record signing Juan Mata cup tied against Olympiakos, Moyes must decide on whether to replace the Spaniard with either the mercurial Portugal international or Antonio Valencia, with the Scot likely to go with the former on the right wing.
CM: Michael Carrick
The home team will need as much big-game experience as is possible on Wednesday evening at the Theatre of Dreams if mission impossible is to become a reality, and there are few more experienced than the England international holding midfielder.
CM: Marouane Fellaini
Alongside Carrick in the centre of the park, by playing further forward in a more attacking role, will be United’s £27.5m summer purchase from Everton, and boy does the big-haired player need to make an impact for his new team soon
LW: Adnan Januzaj
One of his side’s few bright sparks in their 3-0 loss to arch-rivals Liverpool on the weekend and United will need more of the young wide man’s pace and energy if they are to unsettle the Greeks.