Robin van Persie v Martin Skrtel
While the Netherlands international may not have enjoyed his greatest ever campaign in front of goal, the 30-year-old has still found the back of the net with some regularity for the Red Devils when he has been fit enough to take his place up front.
And despite all the rumours and stories linking the Dutchman with a shock move away from Old Trafford come the end of the campaign, you know full well that Van Persie would love nothing better than to get his name on the scoresheet this weekend against the Merseuside giants, as he did in both league encounters last season.
Charged with the task of preventing RVP from netting in the north west will be the visitors’ in-form central defender, one of the few centre backs that Reds head coach Brendan Rodgers has been able to call upon consistently so far in this campaign, with the Slovakia international responding with the best form since he arrived at Anfield six years ago.
Consequently, this will be a personal duel to keep an eye on.