With both teams fielding makeshift lineups, it’s hard to say who will be taking on who on the pitch, but it’s likely that the game will be decided by these individual battles.
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5) Louis Van Gaal v Arsene Wenger
With both sides suffering from serious injury problems, the two managers will have an even greater impact on the game than usual. Their decisions on who should fill in where are of vital importance; and they must use their substitutions carefully, given that they will both be playing several half-fit players who may need to come off without much warning.