Nacho: With Marcelo ruled out for several weeks with injuries, we’re expecting Nacho to step in at right-back.
Luka Modric: Likely to retain his place as the side’s metronome despite a fairly anonymous showing in the Clasico.
Casemiro: Toni Kroos may well be rested for this one, meaning that there could be a start for Brazil midfielder Casemiro. He will be a tenacious presence in the heart of the midfield, but can he keep his discipline.
Gareth Bale: A disappointing performance in the Clasico, but the Welsh forward will find much more space and time to thrive against Shakhtar. Can he rediscover his best form as he steadily makes his way back to full fitness?