Injuries have hit the squads of both teams
Portugal and Argentina play each other on 18 November, with the match being billed as a face off between Cristiano Ronaldo and Lionel Messi.
While these two are great players, there are a number of other stars on show at Old Trafford.
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Players from Manchester United, Barcelona, and Real Madrid will all be taking the field in the highly anticipated friendly.
Here is a combined XI, not including injured players Marcos Rojo and Fabio Coentrao.
GK) Rui Patricio
The Sporting Lisbon goalkeeper has been a regular for Portugal for years now, and beats competition from Argentina’s Willy Caballero and Sergio Romero for the position.