The two sides go head-to-head at the Emirates.
One of the big clashes of the midweek Premier League fixture list is Arsenal v Southampton at the Emirates Stadium, with both teams capable of taking all three points from the fixture.
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The Gunners beat West Bromwich Albion at the weekend, but have struggled in general and although the Saints lost to Manchester City on Sunday they had been in fine form up until that defeat.
As always Arsene Wenger has injury problems to worry about and here is how CaughtOffside thinks the North Londoners will lineup.
GK – Damian Martinez
With both preferred No.1 Wojciech Szczesny and backup David Opsina injured, Wenger will have to once again turn to Martinez – with the young goalkeeper having been solid in recent times.
RB – Calum Chambers
Mathieu Debuchy is back in training, but still some way off returning to the first team and therefore Chambers will need to continue in the back line having impressed so far since a summer switch.
CB – Per Mertesacker
The German has been the only regular in the back four who has been ever present this season and with Laurent Koscielny having only just returned from injury himself the 30-year-old needs to lead by example.
CB – Laurent Koscielny
Although it will be two games in three days for the Frenchman, Wenger has little choice but to play Koscielny with his options at the back woefully limited currently.
LB – Mathieu Flamini
The boss has admitted Kieran Gibbs and Nacho Monreal could both miss out which means that Flamini could reprise a role he occupied during his first spell in North London.