Emirates Stadium side will field experienced first-team stars in North London derby.
Wenger is usually well known for opting to blood young unproven talents in League Cup action but is set to recall Olivier Giroud to lead his attack, the Frenchman having been dropped for Arsenal’s 2-0 defeat to Chelsea.
The Arsenal boss will also select David Ospina, Mathieu Flamini, Mikel Arteta and Alex Oxlade-Chamberlain for the tie at White Hart Lane.
Giroud has netted twice in Premier League action thus far this term but Arsene Wenger opted to use Walcott during Saturday’s Chelsea encounter, the England man having impressed in recent weeks.
The 28-year-old French international was sent off during Arsenal’s 2-1 Champions League defeat to Dinamo Zagreb and will hope to make the most his involvement in midweek.