Villas-Boas has already drawn up a short list of top-level replacements for departing Welshman.
Tottenham Hotspur will reinvest some of the proceeds from the imminent sale of star man Gareth Bale to Real Madrid by buying highly rated FC Porto front man Jackson Martinez this summer, according to reports in the Sunday Times.
The north London club have already privately accepted that the Wales international has now played his final game at White Hart Lane, with chairman Daniel Levy and majority shareholder Joe Lewis set to fly to the United States on Monday for face-to-face talks with their counterpart from the Santiago Bernabeu, Madrid president Florentino Perez.
And it is understood that the duo will demand a fee in excess of £100 million for the 24-year-old, with Tottenham head coach Andre Villas-Boas having already drawn up a short list of potential replacements for the wide man.
The Portuguese, who secured the club-record £26.5m purchase of Valencia striker Roberto Soldado last week, now wants one more top-level centre forward with which to partner the Spain international up front in the capital next season.
And that man is believed to be Colombia international Martinez, with the 26-year-old having just enjoyed a fine debut campaign in front of goal for the Portuguese champions.
Martinez netted an impressive 34 goals in only 39 appearances for Porto last time out, including 26 strikes in only 30 league outings for the club, although with a contract at the Dragao that runs until 2016, Martinez is expected to cost Spurs £22m to buy.