Sinisa Mihajlovic’s side headed into this one on the back of two straight league victories and were aiming to make it three in a row for the first time in over a year.
However, they came unstuck inside the opening 10 minutes when Blerim Dzemaili’s free kick caught out Diego Lopez following a deflection off Giacomo Boneventura.
Any hopes of a Rossoneri revival were thwarted by several incidents of poor finishing, notably from Mario Balotelli, who was unable to recreate his recent heroics.
The former Liverpool and Manchester City frontman missed a series of chances which could have given the Rossoneri a route back into the contest.
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The victory was Genoa’s third straight win over the Lombardy giants—the first time they have achieved such a feat since before the Second World War.
After the match, coach Mihajlovic criticised his players for their error-prone performance—accusing them of losing too many individual battles—and it was abundantly clear that there remains a lot more work to be done before the Rossoneri can be considered as the giants they once were.